Randomised Evaluation of Dynamic Interpersonal Therapy (REDIT)

  • Research Project Team

    • Professor Peter Fonagy,
    • Professor Alessandra Lemma,
    • Professor Mary Target,
    • Professor Stephen Pilling,
    • Professor Anthony Roth,
    • Sally Parkinson

    Contact

    Sally.Parkinson@annafreud.org

  • Background

    Depression is a serious and growing global health problem and previous research has shown that psychological therapies are as effective as medication in its treatment.

    In the UK, the NHS has developed 'Improving Access to Psychological Therapies' (IAPT), which aims to widen clients’ choice of available therapies for depression and anxiety. The options offered by IAPT follow national recommendations (as outlined by the NICE guidelines), which highlight Short-Term Psychodynamic Psychotherapy (STPP) as one of the treatment types that can be effective for adults with depressive illness.

    There are several forms of STPP, one of which is Dynamic Interpersonal Therapy (DIT). While there is evidence that STPP is generally effective, the DIT package continues to be perfected, so it is important to investigate it through a full, large-scale research study and broaden the evidence for its effectiveness within IAPT services. The REDIT study has been funded by NIHR Research for Patient Benefit (RfPB) Programme

    A sub-branch of the trial (fMRI-REDIT) involves fMRI scanning with REDIT participants.

  • Aims

    • The REDIT study is investigating the effectiveness of DIT within IAPT services. It aims to benchmark the effectiveness of DIT at treating adult depression within an IAPT setting, and to assess the requirement for a large trial of DIT and CBT in the future.
    • Alongside the trial, the fMRI-REDIT sub-study aims to explore which brain mechanisms correspond to different depressive symptoms, and which patterns of brain activity may predict how well participants might respond to study interventions.
  • Methodology

    The REDIT study is a single-blind, multi-site, randomised controlled trial feasibility study. The study will compare the outcomes of clients diagnosed with depression who are receiving immediate DIT, with those of patients on an enhanced wait list.

    100 adults with a depressive illness will be recruited and randomly allocated either to immediate DIT for 16 weeks or to the enhanced wait list condition. Outcome assessments take place with participants at treatment midpoint, end of treatment and 12 months later.

    An additional feasibility study is running alongside the REDIT trial, where 40 participants with depression will be randomly allocated to receive DIT or CBT. This feasibility trial is assessing the requirements for a large scale trial, which will help to prepare for a full randomised controlled trial in the future which will compare DIT and CBT within IAPT services.